The glutathione system state in rats exposed to ethanol intoxication, its combination with caffeine and modified photoperiod

Objective. To study the content of reduced glutathione (GSH), activities peroxidase (GP) and glutathione-S-transferase enzymes (GST) in blood liver rats exposed to subacute alcohol intoxication, its combination with caffeine intake or constant light exposure, possibility their correction melatonin.Materials methods. Experiments were performed on 42 male weighing 180-200 g kept under standard conditions vivarium artificial equinox. Alcohol intoxication was induced by intragastric administration 40 % ethanol at a dose 7 ml/kg body weight for days. Caffeine administered gavage 30 mg/kg weight.Results. Ethanol poisoning exposure resulted decrease GSH level GP activity RBCs liver, besides ethanol+light more pronounced depletion parameters. The less reduction (by 25%) but 45% vs. control) than ethanol-treated rats. There an elevation GST all groups alcoholized animals. Administration 5 melatonin days limited prevented changes animals.Conclusions. Melatonin ethanol-induced toxicity limiting preventing